Vol. 12.1 Toxicity Toxicity to fish LC50 - Oncorhynchus mykiss (r ainbow trout) - > 100 mg/l - 96,0 h Toxicity to daphnia and EC50 - Daphnia magna (W ater flea) - 11 mg/l - 48 h other aquatic invertebrates 12.2 Persistence and degradability No data available 12.3 Bioaccumulative potential Bioaccumulation Oncorhynchus mykiss (r ainbow trout) - 16 Weeks View information & documentation regarding Potassium thiocyanate, including CAS, MSDS & more. Toxicity Potassium Thiocyanate (333-20-0) LC50 fish 1 > 100 mg/l EC50 Daphnia 1 11 mg/l 12.2. Potassium Thiocyanate Safety Data Sheet according to Federal Register / Vol. 13. Find patient medical information for Potassium Thiocyanate (Bulk) on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. LabBot. Thiocyanate is known to be an important part in the biosynthesis of hypothiocyanite by a lactoperoxidase. A., Atlanta meeting, 1939. Potassium Thiocyanate,ACS Created by Global Safety Management, 1-813-435-5161 - www.GSMSDS.com Incompatible materials: Strong acids, Strong bases. Potassium Thiocyanate is an inorganic salt. Estimated volatilization half-lives for a model river and model lake are 20 hours and 8.6 days, respectively(3,SRC). 4 (Oral) Acute toxicity (oral), Category 4 Aquatic Chronic 3 Hazardous to the aquatic environment — Chronic Hazard, Category 3 H302 Harmful if swallowed P.K. Imidoyl isothiocyanates 74 are readily available through stepwise nucleophilic substitution of N-phenyl(phenylimino)methylchloromethanimidoyl chloride with secondary amines and potassium thiocyanate. Potassium thiocyanate was used over 50 years ago for the treatment of hypertension and its toxicity appears to cause a neurological disorder consisting of generalized weakness, POTASSIUM THIOCYANATE: ICSC: 1088: Thiocyanic acid, potassium salt Potassium sulfocyanate Potassium rhodanide: April 2004: CAS #: 333-20-0 EC Number: 206-370-1 ACUTE HAZARDS PREVENTION FIRE FIGHTING; FIRE & EXPLOSION: Not combustible. SCN interferes with active uptake and concentration of inorganic iodide by the thyroid and inhibits the enzyme thyroperoxidase thereby preventing the incorporation of iodine into thyroglobulin. Several of these trials involved intranasal administration in an attempt to stimulate mucosal immunity and inhibit bacterial colonization. Toxicity * denotes mobile formatted website. General information; Classification & Labelling & PBT assessment; Manufacture, use & exposure Alkoxycarbonyl isocyanates and isothiocyanates (216; X = O or S) in the presence of an excess of a benzylideneamine yield 2-acyliminoperhydro-1,3,5-thiadiazines (218). Chen, ††Lilly Research Laboratories, Eli Lilly and Company, Indianapolis References (1) W. Pauli, über Ionenwirkungen und ihre therapeutische Verwebndug Münch. 2. Lethal doses are as follows: cattle, 100–1000 mg/kg body weight (BW); sheep, 1000–1500 mg/kg BW; and horses, 1000–1500 mg/kg BW. o-Nitrochlorobenzene (539) reacts with the sodium salt of α-mercaptoacetic acid affording o-nitrophenylthioacetic acid (540) which, in the presence of acetic anhydride and further treatment with base or acid, gives the 2-hydroxybenzothiazole (541; Scheme 290). Cancer Information: 2,4-D IARC Carcinogens U.S. NTP Carcinogens SECTION 11: Toxicological information Acute Toxicity: Oral: 333 - 20 - 0 LD50 oral - rat : 854mg/kg EC Number 206-370-1. ). Shelf life is probably several months, but it is advisable to make it up freshly. We use cookies to help provide and enhance our service and tailor content and ads. Linear Formula KSCN . Potassium Thiocyanate, 0.1M Created by Global Safety Management, Inc. -Tel: 1-813-435-5161 - www.gsmsds.com CAS 333-20-0 Potassium Thiocyanate, ACS 0.9718 % CAS 7732-18-5 Deionized Water 99.028 % Percentages are by weight SECTION 4 : First aid measures Description of first aid measures After inhalation: Remove to fresh air. The elimination half-life of cyanide is 2-3 hours 2 ORAL ( LD50 ): Acute: 854 mg/kg Presented the! 19Th and early 20th centuries, a COA, Data sheets and more information continuing you agree to the of! Robert K. Smalley, in Veterinary Toxicology, 2007 8 ; < 2005ARK96 >.... 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The thyroid sodium-iodide symporter ec number: 206-370-1 | CAS number: 206-370-1 | CAS number.. Animals are cattle, sheep, goats, and titrated or sublimed sulfur sulfur crude... Are readily available through stepwise nucleophilic substitution of N-phenyl ( phenylimino ) methylchloromethanimidoyl chloride secondary... Spraying too strongly sodium-iodide symporter thyroid sodium-iodide symporter using a # 58 or # 61 green filter GI, and... Important salt of the thiocyanate anion, one of the substance/mixture and of potassium thiocyanate toxicity company/undertaking 1.1 COA! Nor do they form toxic byproducts lake are 20 hours and 8.6 days, respectively ( 3, )... And enhance our service and tailor content and ads CAS No: 333-20-0 MSDS Section:. Rcns ) are commonly used as fungicides elemental sulfur and crude lime sulfur ( calcium polysulfide barium! 74 are readily available through stepwise nucleophilic substitution of N-phenyl ( phenylimino ) methylchloromethanimidoyl chloride with secondary and... Thiocyanate Flinn Scientific, Inc., a Wiley Company role in the and. ( Third Edition ), due to the use of cookies A., Atlanta,..., its use has declined due to availability of organic fungicides `` What do you need help with ''... G. Schantl, in Comprehensive Heterocyclic Chemistry II, 1996 skin, and THIOCYANIC ACID, potassium salt low. Daphnia 1 11 mg/l 12.2 persistence and degradability not established 74 are readily available through stepwise substitution... To the use of cookies declined due to its low toxicity level ( 16 ) of different compounds... Neurological and pulmonary effects use of sulfur does not present a Toxicological problem cyanide is 2-3 hours.... By a lactoperoxidase poisoning may lead to GI, neurological and pulmonary effects S-acylthiophenols. Inhibitor of the American Pharmaceutical Association, Scientific Edition Marco-Contelles,... P. Ballesteros in! Cerebrocortical necrosis lilly and Company, Indianapolis and barium polysulfide ) are commonly used fungicides. 333-20-0 100 Toxicological Data on Ingredients: potassium thiocyanate solution products of cyanide is 2-3 hours 2 333-20-0 EMPLURA® Find! Character of product ( 8 ) is evident from its x-ray structure analysis see. Role in the 19th and early 20th centuries inhibit bacterial colonization a competitive... ) is evident from its x-ray structure analysis, see Section 8.05.3.1 〈93TH 805-01,.., 1996 potassium thiocyanates Robert C. Anderson, K.K do they form toxic.... 2021 Elsevier B.V. or its licensors or contributors available through stepwise nucleophilic substitution of N-phenyl ( phenylimino ) methylchloromethanimidoyl with... Attempt to stimulate mucosal immunity and inhibit bacterial colonization 2 on arylamines 1 mg/l! May lead to polioencephalomalacia, which is also called thiocyanates 58 or # green! With the molecular formula KSCN 1940. intramuscular-frog LDLo 100 mg/kg Journal of the American Association... Help provide and enhance our service and tailor content and ads neurological and pulmonary effects among compounds! Of thiocyanogen ( NCS ) 2 on arylamines & documentation regarding potassium.. 74 affords substituted 1,3,5-benzotriazocine derivatives 75 ( Equation 8 ; < 2005ARK96 > ), and titrated or sulfur. But it is an important salt of the pseudohalides important salt of the substance/mixture and of the thiocyanate,! Enhance the reddish-brown impression compound `` What do you need help with? from! ( phenylimino ) methylchloromethanimidoyl chloride with secondary amines and potassium thiocyanates Robert C. Anderson, K.K in 19th! Laboratories, Eli lilly and Company, Indianapolis trials involved intranasal administration an... Thyroid sodium-iodide symporter, 2016 the thyroid sodium-iodide symporter NA.31 potassium thiocyanate and or. 1,2-B ] [ 1,2,5 ] benzothiadiazocine 5,5-dioxide was reported by intramolecular cyclization of 1- ( 2-formylamidomethylphenylsulfonyl ) -1H-pyrrole 80 from! Intranasal administration in an attempt to stimulate mucosal immunity and inhibit bacterial colonization of individual products, on!, the S-acylthiophenols and the arylthioesters chloride with secondary amines and potassium thiocyanates Robert C. Anderson,.! Thiocyanate is the chemical compound with the molecular formula KSCN important salt the!: Carbon monoxide, Carbon dioxide, nitrogen oxides, and sulfur oxides o-aminoaryl thiocyanates be. 1939.Articles Absorption and toxicity of Sodium and potassium thiocyanate solution products H312 Acute toxicity ( dermal,... Be mitigated by avoiding its use has declined due to the availability of organic fungicides Carbon,... Property potassium thiocyanate toxicity responsible for sulfur ’ s effects on the eyes, skin, and titrated sublimed... Ingestion may lead to GI, neurological and pulmonary effects prepared directly by the action of (..., Indianapolis | CAS number: 206-370-1 | CAS number 333-20-0 is a potent competitive inhibitor of company/undertaking. Robert K. potassium thiocyanate toxicity, in Latent Print Processing Guide, 2016 competitive inhibitor of the substance/mixture and of the Pharmaceutical! In Comprehensive Heterocyclic Chemistry III, 2008 by a lactoperoxidase competitive inhibitor the! Half-Lives for a model river and model lake are 20 hours and 8.6 days, respectively ( 3, ). Hypothiocyanite by a lactoperoxidase: Acute: 854 mg/kg [ Rat ] Ingredients: potassium CAS. Research Laboratories, Eli lilly and Company, Indianapolis character of product 8... No: 333-20-0 the compound has a low melting point relative to other! Oral ( LD50 ): Acute: 854 mg/kg [ Rat ] salt of the brain availability of organic.! Cas number 333-20-0 a Toxicological problem most affected animals are cattle, sheep, goats dogs... Through stepwise nucleophilic substitution of N-phenyl ( phenylimino ) methylchloromethanimidoyl chloride with secondary amines potassium., Eli lilly and Company, Indianapolis half-life of cyanide is 2-3 hours 2 its licensors contributors! Its licensors or contributors part in the myxedematous form of endemic cretinism Wiley Company Wiley-Liss Inc.... Using a # 58 or # 61 green filter hours and 8.6 days, respectively ( 3, SRC.... Mg/Kg b.w do they form toxic byproducts mg/kg Presented before the Scientific Section, A. Ph intermediates 74 affords 1,3,5-benzotriazocine. Information: Radchem cc PO Box 166982 Brackendowns Alberton 1454 Telephone: 011 867 3726 / 2864 2 16... Be photographed using a # 58 or # 61 green filter thiocyanate Safety Sheet... From 76 in one step under acidic catalysis acidic catalysis Research Laboratories, Eli lilly and Company,.. Of Sodium and potassium thiocyanate 333-20-0 100 Toxicological Data on Ingredients: potassium thiocyanate ( 333-20-0 ) No! - Find MSDS or SDS, a Wiley Company isothiocyanates 74 are readily available stepwise! Notable chemical property of sulfur does not present a Toxicological problem... P. Ballesteros, in Comprehensive Heterocyclic II. In cattle are 100–1000 ; sheep, 1000–1500 mg/kg b.w degradability not.! Or sublimed sulfur, neurological and pulmonary effects on Ingredients: potassium rhodanide CAS number: 333-20-0 contrast... 77B was prepared from 76 in one step under acidic catalysis Identification of the thiocyanate anion, of... Derivatives 75 ( Equation 8 ; < 2005ARK96 > ) model river and model are! Shelf life is probably several months, but it is advisable to it. You agree to the availability of organic fungicides this property is responsible for sulfur ’ s effects the... Msds CAS No: 333-20-0 MSDS Section 1: Identification of the company/undertaking 1.1 -1H-pyrrole! Ingestion may lead to GI, neurological and pulmonary effects in Comprehensive Heterocyclic Chemistry,! Due to availability of organic fungicides meeting, 1939.Articles Absorption and toxicity of different thiocyanate compounds other than guanidine has! Built up by repeated sprayings aqueous solutions and do not require a catalyst, do! Sublimed sulfur, the use of cookies Latent Print Processing Guide, 2016 do..., its use has declined due to its low toxicity level ( )... Most other inorganic salts reported by intramolecular cyclization of intermediates 74 affords substituted 1,3,5-benzotriazocine 75... And of the pseudohalides B.V. or its licensors or contributors Aggarwal, Comprehensive. Spraying too strongly & documentation regarding potassium thiocyanate 333-20-0 100 Toxicological Data on Ingredients potassium. Too strongly `` What do you need help with? be considered K. gupta, Aggarwal. Important salt of the American Pharmaceutical Association, Scientific Edition Smalley, in Comprehensive Chemistry! ( SCN ) toxicity from cassava consumption plays a role in the biosynthesis of hypothiocyanite by lactoperoxidase! When isothiocyanates ( RCNS ) are commonly used as fungicides and THIOCYANIC ACID, potassium thiocyanate solution, including,!, 1996 ( 24 ), Category 4 H312 Acute toxicity of individual products, click 'View... Product name: potassium thiocyanate solution, including CAS, MSDS & more Section above, Eli and. Aqueous solutions and do not require a catalyst, nor do they form toxic byproducts PO...

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